Paraguay’s drug landscape is shifting, with synthetic drugs like ecstasy gaining ground among young people, according to a report by Ultima Hora. In March 2026, authorities in Fernando de la Mora confiscated 50,000 doses of ecstasy—a record haul for the country. The seizure alarmed officials and highlighted the growing availability of MDMA, the active ingredient in ecstasy.
While marijuana remains the most widely consumed illegal drug in Paraguay, followed by cocaine and crack (known locally as chespi), ecstasy has emerged as a significant concern. The Drug Enforcement Administration (DEA) classifies MDMA as a synthetic drug that acts as both a stimulant and hallucinogen, producing effects such as euphoria, increased energy, distorted perception, and heightened empathy. However, it also carries severe risks: elevated body temperature (hyperthermia), liver, kidney, or cardiovascular failure, brain swelling, and even death.
Francisco Ayala, director of Communications for Paraguay’s National Anti-Drug Secretariat (Senad), warned that ecstasy should never be mixed with alcohol, as it nullifies alcohol’s effects. “Those who consume ecstasy only drink water. At electronic or youth parties, water costs more than beer,” he told Ultima Hora. He noted that users often consume large amounts of water because the drug rapidly raises body temperature and causes dehydration.
According to investigations cited by the outlet, Ciudad del Este is the epicenter of ecstasy consumption in Paraguay, though use is also reported in nightclubs and pubs in Asunción and the Central Department. Authorities have discovered clandestine laboratories in Ciudad del Este that produce the drug, some of which is trafficked to Brazil.
The record seizure and rising use of ecstasy reflect a broader trend: synthetic drugs are becoming more accessible, and their dangers are often underestimated by young partygoers. The Senad continues to monitor the situation, but the challenge of curbing demand and supply remains acute.